Human Folate Requirements
نویسندگان
چکیده
منابع مشابه
Folate Requirements of Methotrexate - Resistant Human Acute Lymphoblastic Leukemia Cell
We studied the folate requirements of a human acute lymphoblastic leukemia cell line, MOLT-3, and methotrexate (MTX)-resistant sublines established in vitro. The requirement of pteroylglutamate (PGA) for optimal cell growth was different for each cell line. With increasing MTX resistance, there was progressive increase in PGA requirements, moving the PGA concentration-cell growth curve (doseres...
متن کاملFolate requirements for health in women.
The earliest account of human folate requirement relates to its critical role in women’s health. In 1872 Biemer described a severe, rapidly progressive and sometimes fatal anaemia of pregnancy (Rodriguez, 1978). However, the possibility that this might be related to a dietary deficiency was not considered until much later, when Wills (1931) established that cases of macrocytic anaemia in pregna...
متن کاملFolate and human reproduction.
The influence of folate nutritional status on various pregnancy outcomes has long been recognized. Studies conducted in the 1950s and 1960s led to the recognition of prenatal folic acid supplementation as a means to prevent pregnancy-induced megaloblastic anemia. In the 1990s, the utility of periconceptional folic acid supplementation and folic acid food fortification emerged when they were pro...
متن کاملHuman Folate Bioavailability
The vitamin folate is recognized as beneficial health-wise in the prevention of neural tube defects, anemia, cardiovascular diseases, poor cognitive performance, and some forms of cancer. However, suboptimal dietary folate intake has been reported in a number of countries. Several national health authorities have therefore introduced mandatory food fortification with synthetic folic acid, which...
متن کاملFolate requirements of methotrexate-resistant human acute lymphoblastic leukemia cell lines.
We studied the folate requirements of a human acute lymphoblastic leukemia cell line, MOLT-3, and methotrexate (MTX)-resistant sublines established in vitro. The requirement of pteroylglutamate (PGA) for optimal cell growth was different for each cell line. With increasing MTX resistance, there was progressive increase in PGA requirements, moving the PGA concentration-cell growth curve (dose-re...
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ژورنال
عنوان ژورنال: The Journal of Nutrition
سال: 1987
ISSN: 0022-3166,1541-6100
DOI: 10.1093/jn/117.12.2162